Source = Brisbane Convention & Exhibition Centre Brisbane Convention & Exhibition Centre was today awarded the title of ‘Worldwide Convention Centre Team of the Year’ at a glittering awards ceremony in London by the leading international publication Conference & Incentive Travel (C&IT).The C&IT Excellence Awards are presented annually to celebrate excellence in the international meetings industry encompassing all areas of operational performance.Brisbane Convention & Exhibition Centre, which is operated by leading international venue management group, AEG Ogden, was shortlisted for the awards alongside two of the world’s leading convention centres – ExCel London and SCEC Glasgow.BCEC’s award submission was based on the launch to the market of the Centre’s $140 million expansion – Australia’s newest convention centre.The Centre’s European based international representative Mary-Jane Wiedemann received the award on behalf of the BCEC team. Mary-Jane is an extension of the Centre’s very experienced International Sales Team. BCEC General Manager, Bob O’Keeffe said the highly sought after award was an honour and ultimate recognition of the Centre’s team for its experience, expertise, professionalism and high levels of personal service.“We have always placed the highest priority on delivering superior standards of professionalism and service excellence and our team takes tremendous pride in all they do. This international award endorses this strategy and the dedication and commitment of all members of our team,” he said.2012 has been a momentous year for the Centre with the opening of BCEC on Grey Street, the Centre’s $140 million boutique expansion and the announcement by the Australian Government of BCEC as the official venue for the G20 Leaders Summit in 2014. This year the Centre was also named Best Meeting Venue for 500 delegates or more in the Meetings & Events Australia (MEA) National Awards.
March 19, 1998Placing the bucket over the slab next to Heat Duct tunnel.
In recent years, some cities, including Memphis and Phoenix, withered into health insurance wastelands, as insurers fled and premiums skyrocketed in the insurance marketplaces that were set up under the Affordable Care Act.But today, as in many parts of the U.S., these two cities are experiencing something unprecedented: Insurance premiums are sinking and choices are sprouting.In the newly competitive market in Memphis, for example, the cheapest midlevel “silver” plan for 2019 health coverage will cost $498 a month for a 40-year-old — a 17 percent decrease compared to last year.And four insurers are now selling ACA policies in Phoenix. That’s the same market that then-presidential candidate Donald Trump highlighted in 2016 because all but one insurer had left the region — he called it proof of “the madness of Obamacare.”Janice Johnson, a 63-year-old retiree in Arizona’s Maricopa County, which includes Phoenix, said her monthly premium for a high-deductible bronze plan will be $207 for 2019, instead of $270, because she is switching carriers.”When you’re on a fixed income, that makes a difference,” said Johnson, who receives a government subsidy to help cover her premium. “I’ll know more in a year from now if I’m going to stick with this company. But I’m going to give them a chance, and I’m pretty excited by that.”Looking across all 50 states, the premiums for the average “benchmark” silver plan, which the government uses to set subsidies, are dropping nearly 1 percent. And more than half of the counties in the 39 states that rely on the federal HealthCare.gov exchange are experiencing a 10 percent price decrease, on average, for their cheapest plan.In most places, the declines are not enough to erase the price hikes that have accrued since the creation of the health care exchanges in 2014.Instead, next year’s price cuts help to correct the huge increases that jittery insurers set for 2018 to protect themselves from anticipated Republican assaults on the markets. While Congress came up one vote shy of repealing the federal health law in the summer of 2017, Trump and Republicans in Congress did manage to strip away many of the structural underpinnings that induced people to buy plans and helped insurers pay for some of their low-income customers’ copayments and deductibles. Insurers responded with a 32 percent increase, on average, for 2018 plans.”Insurers overshot last year,” said Chris Sloan, a director at Avalere, a health care consulting company in Washington, D.C. “We are nowhere close to erasing that increase. This is still a really expensive market with poor benefits when it comes to deductibles and cost.”For 2019, the average premium for the benchmark silver plan will be 75 percent higher than it was in 2014, according to data from the Kaiser Family Foundation. (Kaiser Health News is an editorially independent program of the foundation.)When Republicans failed to kill the health law last year, they inadvertently may have made it stronger. Insurers banked hefty profits in 2018, and that attracted new companies to most ACA markets.All these factors were especially influential in Tennessee, where the average benchmark premium is dropping 26 percent, according to an analysis by the federal government. That’s a bigger drop than in any other state.Seventy-eight of 95 Tennessee counties had just one insurer for 2018. That monopoly allowed the insurer to set the prices of its plans without fear of competition, said David Anderson, a researcher at the Duke-Margolis Center for Health Policy in Durham, N.C. “They were massively overpriced,” Anderson said of all available policies.But for the coming year, 49 Tennessee counties will have more than one insurer, with a few — like Shelby County, where Memphis is located — having four companies competing. There, Cigna dropped the price of its lowest-cost silver plan by 15 percent. Even then, Cigna was underbid by Ambetter of Tennessee, a company owned by the managed-care insurer Centene Corp.”We’re finally at the point where the market is stabilized,” said Bobby Huffaker, the CEO of American Exchange, an insurance brokerage firm based in Tennessee. “From the beginning, every underwriter — [and] the people who were the architects — they knew it would take several years for the market to mature.”Still, the cheapest Memphis silver premium is nearly three times what it was in 2014, the first year of the marketplaces. A family of four, headed by 40-year-old parents, will be paying $19,119 for all of next year unless they qualify for a government subsidy.”The unsubsidized are leaving,” said Sabrina Corlette, a professor at Georgetown University’s Health Policy Institute. “They are finding these premiums unaffordable.”The landscape in Phoenix is greatly improved from when Trump visited after the federal government announced a 116 percent premium increase for 2017; the number of insurers at that time had dropped from eight to one.Now, three new insurers are entering Maricopa County. Meanwhile, Ambetter, the only insurer that offered plans for 2018, reduced its lowest price for a silver plan for next year by 12 percent — and it offers the cheapest such plan in the market.Still, Ambetter’s plan is 114 percent above the least expensive silver plan offered there in the first year of the exchanges. And neither Ambetter nor any of the insurers coming into the market for 2019 offer as broad and flexible a choice of doctors and hospitals as consumers had back then, according to Michael Malasnik, a local broker.Since the start of the exchanges, Malasnik said, insurers have “raised their rates by multiples, and they’ve figured out you have to be a very narrow network.”Each plan in Phoenix for 2019 contains trade-offs, he said. Only Bright Health’s plan includes Phoenix Children’s Hospital. Ambetter’s plan includes the most popular hospital and doctor groups, Malasnik said. But those providers are not as conveniently located for people living in the southeastern corner of the county, and that makes other insurers’ plans more appealing for some customers.”Geography is the name of the game this year,” Malasnik said.Theresa Flood, a preschool teacher who lives outside Phoenix, said none of the provider networks of the plans she considered included her doctors, such as the specialist who treats her spine problems. She has had four surgeries, and a neurologist who monitors a cyst and benign tumor in her brain is also outside the network she ended up choosing.”I have to establish care with a whole new spine doctor and establish care with a whole new neurologist if I want to follow up on these things,” said Flood, who is 59. “You’re going from ‘established care’ to ‘who in the heck am I going to see?’ “The plan Flood ultimately chose would have been too expensive, except that she and her husband John, who is a minister, qualified for a $1,263-a-month subsidy that will drop the cost to $207 a month. That bronze plan from Ambetter carries a $6,550-per-person deductible; so Flood expects she’ll still have to pay out-of-pocket for her treatments and doctor visits unless she needs extensive medical attention.”It’s gone from being able to have a plan that you could sort of afford and got some benefit from, to putting up with what you can afford and hoping nothing happens that you actually have to use your insurance,” she said. “At this point, I’ll take what I can get.”Kaiser Health News, a nonprofit news service, is an editorially independent program of the Kaiser Family Foundation, and is not affiliated with Kaiser Permanente. Copyright 2018 Kaiser Health News. To see more, visit Kaiser Health News.
6 min read Image credit: Shutterstock March 20, 2018 Entrepreneur Staff Facebook’s Brand Is Becoming the Uber of Social Media, and That’s Not a Good Thing Fireside Chat | July 25: Three Surprising Ways to Build Your Brand Once upon a time less than five years ago every startup in existence pitched itself as the Uber of whatever it did. Nobdy frames their startup that way anymore. An ever unspooling series of scandals running the gamut from raunchy corporate culture to deliberately evading municipal regulators and alleged theft of trade secrets led to the ouster of Travis Kalanick, who now lives in exile and is remembered as the CEO who yells at his lowest-paid employees when they voice a complaint.Facebook and its famously boyish founder and CEO Mark Zuckerberg appear to be spiraling toward the same branding calamity. The corporation and the man have consistently denied or downplayed Facebook’s role as a chief purveyor of Russian misinformation during the 2016 presidential campaign. An avalanche of new problems is burying Facebook with revelations that its loosey-goosey privacy rules allowed Cambridge Analytica, the company at the center of the scandal surrounding clandestine Russian involvement in the 2016 election, to “harvest” data from up to 50 million people without their permission (or, in the vast majority of cases, their knowledge) to sharpen the 2016 presidential campaigns of, first, Ted Cruz, then Donald Trump.The reporting on the Cambridge Analytica scandal is must reading no matter how burned out you are on politics and scandals. It reveals that Facebook operates a lot like a bar that doesn’t check ID — if you can pay for your drink, you get served and what happens after that is not their worry. In this instance, Cambridge Analytica — the data research firm owned by Steve Bannon and billionaire Robert Mercer, the same pair who brought us Breitbart News — hired a Cambridge University professor, Alexander Kogan, to entice Facebook users to download an app that vacuumed up their personal information as well as their Facebook friends.Related: Russian-Linked Facebook Ad Scandal Shows Just How Intricate Targeting Can BeThe data was supposed to be used for academic research but, as we know now (and Facebook has known for a long time but told nobody), it was used to draw exquisitely detailed profiles of American voters to guide how they were pitched during the 2016 campaign. Facebook is defensively arguing what is looking like one of the largest data breaches ever is not, in the narrowest possible sense, a data breach. As they explain it, everyone who dowloaded Kogan’s app agreed to surrender their data, but Kogan used the data he acquired in violation of his agreement with Facebook.That is something like telling a person who believes they have been robbed they are really victims of an embezzlement, so calm down and realize it isn’t Facebook’s fault. Alex Stamos, Facebook’s outgoing chief of security, seems to be among the many people skeptical of this explanation. According to The New York Times, Stamos has resigned from Facebook because of “internal disagreement rooted in how much Facebook should publicly share about how nation states misused the platform and debate over organizational changes in the run-up to the 2018 midterm elections.”Stamos advocated disclosing more about how the Russians rigged Facebook and he advocates trying harder to keep them out of the upcoming elections. Zuckerberg, you will recall, in November 2016 dismissed as a “pretty crazy idea” that Russians had used Facebook to spread fake news. That was the same month Stamos’s team had already confirmed the Russians had done exactly that.Stamos, who once oversaw 120 people, was all but fired in December and left to oversee a staff of three.Related: Here Are the Russia Facebook Ads That Tried to Dupe YouZuck will be flushed from his comfort zone.The fall from grace of Facebook and huge social media companies in general (Twitter is better know known for Russian bots than earnest public debate) is likely to result in more regulation and more energetic scrutiny from regulators. Lawmakers in the U.S., U.K. and EU are clamoring for Zuckerberg personally to testify before investigating committees. Zuckerberg has only dispatched other executives to do that, and their testimony has been widely seen as evasive.“I will be writing to Mark Zuckerberg asking that either he or another senior executive from the company appear to give evidence in front of the committee as part our inquiry,” British lawmaker Damian Collins, head of a parliamentary committee that has been investigating Facebook and Cambridge Analytica, said to The Washington Post. “It is not acceptable that they have previously sent witnesses who seek to avoid difficult questions by claiming not to know the answers.”U.S. lawmakers seem intent on hearing from Zuckerberg himself.Related: Facebook Says 126 Million Users May Have Been Exposed to Russian Posts“They say ‘trust us,’ but Mark Zuckerberg needs to testify before the Senate Judiciary Committee about what Facebook knew about misusing data from 50 million Americans in order to target political advertising and manipulate voters,” Sen. Amy Klobuchar (D-Minn.) said in a statement.Being hauled in front of congressional committees for a public grilling is just the unpleasant beginning for Zuckerberg and his company. Public outcry is likely to give new momentum to legislation to regulate political advertising on social media just as it is regulated in legacy media. Equally likely is heavy pressure on the Federal Trade Commission to enforce a 2011 consent order supposedly governing how Facebook protects release of user data to third parties. The order calls for fines of up to $40,000 per breach of privacy. The penalties for compromising the data of 50 million people could, at least in theory, run into the billions of dollars. The Electronic Privacy Information Center, which led the public movement that resulted in the consent order and has since sued the FTC for failure to enforce it, argues this latest data loss underscores the need for a national data protection law and a standalone agency to enforce it.“This is the consequence of the Federal Trade Commission’s failure to enforce the 2011 consent order with Facebook,” Marc Rotenberg, president of the Electronic Privacy Information Center, told The Washington Post. “The United States needs a dedicated privacy agency and a comprehensive privacy law. The FTC can’t do the job.”Related: Mark Zuckerberg ‘Dead Serious’ About Stopping Russian Facebook AbuseThere are limits to how bad it gets when your brand is tarnished. Uber, after all, remains an enormous and growing company likely to only get richer. Kalanick, wherever he is and whatever he is doing, remains a billionaire. It’s just neither is esteemed any longer or used as an example of excellence. Facebook, vastly larger and far more central to the daily life of many more people, is in no danger of going out of business, just as Zuckerberg is certain to remain one of the wealthiest people on Earth. How much it or he is respected or admired is much more uncertain. Peter Page Next Article Senior Editor for Green Entrepreneur Learn from renowned serial entrepreneur David Meltzer how to find your frequency in order to stand out from your competitors and build a brand that is authentic, lasting and impactful. Add to Queue –shares Facebook Facebook and its founder Mark Zuckerberg have squandered the public’s good will by downplaying just how compromised the platform was during the 2016 election. Enroll Now for $5
Add to Queue Green Entrepreneur Podcast December 7, 2018 –shares News and Trends Earlier this week at the International Cannabis Policy Conference, which is being held at United Nations Headquarters in Vienna, Austria, participants were very excited about the prospects of the United Nations World Health Organization rescheduling the legal status of the plant.All signs looked promising. Last May, the UN released its first-ever review of marijuana, offering some positive assessments. And earlier this month, the Federal Drug Administration got involved, asking the American people what they thought the U.S.’ recommendation should be.But, in a somewhat surprising blow, the World Health Organization’s Expert Committee on Drug Dependence came out with an announcement saying it would decline to give recommendations or reschedule cannabis. The Committee argued it needed more time to complete a thorough critical review.“It’s unfortunate to hear the news on the decision from the WHO,” said Evan Eneman, CEO of the MGO/ELLO Alliance. “Every day we see more and more researchers, health institutions, investors, large multinational operators and entrepreneurs entering the space to support the sustainable growth of this industry.”Related: FDA Welcomes Public Comments on MarijuanaShaken But Not SurprisedWhile many experts in the cannabis industry are disappointed, not all are surprised. Emily Paxhia, co-founder and managing partner at cannabis-focused hedge fund Poseidon Asset Management, noted that the cannabis industry is used to seeing “progress coupled with setbacks.” Hurdles are inherent to the nature of this space, she added. “We are always optimistic and hopeful about seeing progress, understanding the plant and studying it further, so we can better comprehend all the positive attributes that the plant can bring to society,” she told Green Entrepreneur. “But, it’s also not that surprising to see that outdated perceptions and misperceptions are holding back adoption of studying, researching and looking more positively into the cannabis plant.”Jonas Duclos, co-founder and CEO of Switzerland-based JKB Research, called the WHO announcement “obviously disappointing but not a real surprise,” explaining that “the main problem is that governments are far behind when it comes to innovation and research. They are not well informed and don’t know the right people to work with.” He sees opportunity in the disconnect. “The cannabis industry has to be led by its real wellness potential, rather than the profits it can beget. Although the WHO is a key actor in this process, this opens the door for others to demonstrate initiative in the short term.”Related: How Bad Is It?But, while many in the cannabis industry were unhappy with the WHO’s decision, some agreed with it.“We need to think of cannabinoids as we do any other plant-derived pharmacological agent that has historically been derived from plants such as paclitaxel, morphine and even codeine,” said Christine Allen, professor at the University of Toronto and Chief Scientific Officer at Avicanna, a Canadian cannabinoid biotech company. “All of these drugs have a safe and effective dose and are contraindicated in certain patient populations. It is critical that the gaps in our knowledge are filled in a timely manner in order to sufficiently educate the medical community and the public,”CEO of Avicanna, Aras Azadian, also agrees with the WHO’s decision. “We have tested many products currently on the market that contain potentially toxic degradants and can be metabolized in the body to compounds with an unknown safety profile. Cannabis has become a cash crop and many unqualified companies are offering these unsafe products to consumers and patients. We’re afraid that many of the benefits patients experience with CBD products specifically may also be a placebo effect as we have tested the bio-availability of CBD products,” he saidWhat’s NextLezli Engelking, founder of the Foundation Of Cannabis Unified Standards, (FOCUS) who tracks issues like these predicts that the WHO won’t take action — if they take action at all — until March of 2020.But he cautions that “given the surprising and novel move by WHO, all bets are off. Policy can always be adjusted — just as it was today. One thing is for sure though: the time is now for the cannabis industry to step up their game and show the world it can produce safe, consistent, quality products that don’t pose an unnecessary risk to patients, consumers, the public, and the environment.”Adding to this point, Eneman said the industry as a whole, and society, have an “obligation to understand exactly what this plant is capable of as well as how it can be misused or abused.“It is clear that this plant in all the existing and contemplated forms is far safer than many other substances we consume. It is also clear as to the direction we are heading, and it is an important time to focus on establishing international trust and transparency for this industry. We need the support from policymakers, operators, financiers and regulators. There have been pioneers for years willing to support the safety and efficacy of the cultivation and consumption of this plant, and there are many many new entrants who want to explore the possibilities of what it can do, including the largest, most credentialed and most influential researchers in the world. WHO and others need to get behind this movement and allow all of the good stewards to help shape the way for a safe, effective and sustainable industry.” Each week hear inspiring stories of business owners who have taken the cannabis challenge and are now navigating the exciting but unpredictable Green Rush. In a surprising development, the U.N. comitee decided to punt on their decision to recommend or reschedule cannabis. VIP Contributor Image credit: Shutterstock The World Health Organization Won’t Reschedule Cannabis. Should We Care? cannabis, biotech and entrepreneurship reporter Opinions expressed by Entrepreneur contributors are their own. Next Article Listen Now 5 min read Javier Hasse
This story appears in the July 2006 issue of Entrepreneur. Subscribe » 2019 Entrepreneur 360 List Export with Ease Next Article –shares July 1, 2006 Laurel Delaney Add to Queue Magazine Contributor 1 min read A free online filing system makes your mandatory paperwork a breeze. Complying with export laws just got simpler. AESDirect, a free and highly sophisticated system, simplifies the process of filing Shipper’s Export Declaration information to the Automated Export System. Though as of press time a date hadn’t been set, it will soon become mandatory to file all your export documentation electronically. AES-Direct offers these benefits:1. Ensures export compliance: It returns a confirmation number to verify that you successfully filed your export documentation.2. Corrects errors: Get immediate feedback when data is omitted or incorrect, and correct errors at any time.3. Eliminates paper review: Say goodbye to the time delays of handling paper.4. Stays up-to-date with various trade agreements: AES conforms to NAFTA and GATT, making it easier to do business in multiple countries.5. Evaluates and measures potential markets: Accurate and timely export statistics help your business stay ahead.For further information, visit AESDirector call the AES hotline at (800) 549-0595.Laurel Delaney runs GlobeTrade.comand LaurelDelaney.com, Chicago-based firms that specialize in international entrepreneurship. Apply Now » The only list that measures privately-held company performance across multiple dimensions—not just revenue. Growth Strategies
Add to Queue Next Article Fireside Chat | July 25: Three Surprising Ways to Build Your Brand It’s a good thing Lady Gaga didn’t quit her day job.The celeb’s startup for building online communities, Backplane, has burned through $18.9 million in funding in five years and is now out of business, TechCrunch reports.Backplane was Gaga’s vision for an online social network, a place where her so-called “little monsters” (that is, Gaga fans) could come and connect.The startup fetched an original $40 million valuation back in 2011, Vanity Fair reports.But the Fame Monster’s bubble has since burst.Backplane launched a single product, LittleMonsters.com, which was born out of Lady Gaga’s fan website. The monsters site was billed as a high-end social media and photo sharing network:The LittleMonsters.com page as it appeared in March 2015Image credit: via Wayback MachineLady Gaga poured $1 million of her own cash into the launch, with Google Ventures, Menlo Ventures, and Google’s Eric Schmidt also funding the endeavor.But since the LittleMonsters.com launch, the company’s seen little success. Now backplane has defaulted on its loans, forcing the company to go belly up, TechCrunch says. A group of investors has bought the company’s assets, everything from the patents to the office space, and is planning to restart the business, TechCrunch adds.Gaga’s fumble comes just as many venture capitalists are tightening their own purse strings, slowing the era of billion-dollar tech startup valuations.But Lady Gaga’s days in Silicon Valley aren’t over yet. The star recently partnered with Intel and Vox Media via her Born This Way Foundation for the new “Hack Harassment” project that will work to quell cyberbullying and sexual harassment on the Internet. Learn from renowned serial entrepreneur David Meltzer how to find your frequency in order to stand out from your competitors and build a brand that is authentic, lasting and impactful. lady gaga Hilary Brueck April 12, 2016 Enroll Now for $5 Lady Gaga’s Startup Just Went Out of Business 2 min read –shares This story originally appeared on Fortune Magazine Image credit: Courtesy of Intel
Reviewed by James Ives, M.Psych. (Editor)Jan 17 2019A Michigan State University study is the first to show an association between unusually high pesticide exposure and poor sense of smell among aging farmers.The research examined more than 11,200 farmers over a 20-year period. At the start of the study, about 16 percent of participants reported having experienced a high pesticide exposure event, or HPEE, such as a large amount of pesticide spilling on their body. Two decades later, they were asked if they suffered olfactory impairment, a partial to complete loss of sense of smell.Farmers who reported an HPEE were 50 percent more likely to report a poor sense of smell at the end of the study. The research also showed that an immediate washing with soap and water might mitigate risk. Compared to farmers who never experienced a high exposure event, those who did and washed within three hours, had about a 40 percent higher risk of having problems with smell. Those who waited four or more hours, saw their risk potentially double.Related StoriesHealthy lifestyle lowers dementia risk despite genetic predispositionAn active brain and body associated with reduced risk of dementiaLiving a healthy lifestyle may help offset genetic risk of dementiaThe study, a collaboration with researchers from the National Institute of Environmental Health Sciences and the National Cancer Institute, is published in the journal Environmental Health Perspectives.”Studying farmers gives us more reliable data on pesticide exposures than if we had studied the general population,” said Honglei Chen, lead author and professor of epidemiology. “Because they use pesticides more and it’s part of their job, they’re more likely to remember what pesticides they used and in cases of high exposures, report the specific events.”In the study, Chen was able to identify two insecticides – DDT and lindane – as well as four weed killers – alachlor, metolachlor, 2,4-D and pendimethalin – that showed a greater association with poor sense of smell.”Farmers reporting incidents, involving unusually high exposures to certain organochlorine insecticides such as DDT and herbicides including 2,4-D, were more likely to have a poor sense of smell,” he said. “More research needs to be done, but some studies have linked these chemicals to Parkinson’s and possibly dementia too.”While poor sense of smell has been shown to be an early symptom of Parkinson’s and dementia, Chen said his study only addresses an association between pesticide exposure and impaired smell, not to neurodegenerative diseases.”Olfactory impairment affects up to 25 percent of our older population, and our understanding of what the consequences are is still very limited,” Chen said. “Studies have also suggested that older adults with a poor sense of smell are more likely to die earlier, so understanding the factors involved is very important.”Source: https://msutoday.msu.edu/news/2019/high-pesticide-exposure-among-farmers-linked-to-poor-sense-of-smell-later/
Source:https://www.elsevier.com/ Reviewed by Alina Shrourou, B.Sc. (Editor)Feb 12 2019Measurement of AHNAK2 helps physicians make challenging diagnostic decisions, according to a new study in The American Journal of PathologyLabel-free digital pathology using infrared (IR) imaging with subsequent proteomic analysis for bladder cancer (BC) has revealed the first protein biomarker (AHNAK2) for BC. AHNAK2 differentiates between chronic cystitis (inflammation of the bladder) and a non-muscle invasive-type BC (carcinoma in situ) which is challenging to diagnose. A report in The American Journal of Pathology describes this new diagnostic procedure, which is label-free, automated, observer-independent, and as sensitive and specific as established histopathological methods.Distinguishing benign inflammatory conditions in the bladder from low-grade and advanced cancers can be difficult, especially since some BC treatments induce inflammation.”We developed this label-free digital pathology annotation system by IR imaging to support the pathologist, similar to driver assistance in cars. This technique in combination with a proteomics approach allowed us to identify AHNAK2 as an important new biomarker for BC, and the results encourage us to transfer this label-free digital technique to other pathologies,” explained Klaus Gerwert, PhD, Chairman of the Department of Biophysics and the PURE (Protein Research Unit Ruhr within Europe) consortium at Ruhr University Bochum, Germany.Using label-free Fourier transform IR (FTIR) imaging, investigators were able to classify unaltered tissue thin sections by color to identify regions of interest. “The resulting index color images automates tissue classification, including cancer type, subtype, tissue type, inflammation status, and even tumor grading,” noted Prof. Dr. Gerwert.In an analysis of 103 freshly-frozen samples that included confirmed diagnoses for 41 cystitis, 19 low-grade carcinoma, and 43 high-grade carcinoma, FTIR imaging showed a specificity of 95 percent, sensitivity of 95 percent, and an accuracy of 95 percent compared to stained images reviewed by a trained pathologist. The technique also differentiated cancerous from healthy tissue as well as low- from high-grade carcinoma.Laser capture microdissection was then used to obtain homogenous tissue samples for protein analysis by proteomics. By comparing tissue from patients with inflammatory bladder (cystitis) to samples from patients with invasive, high-grade urothelial carcinoma, the investigators identified three potential biomarkers, with the protein AHNAK2 found to be the best performing candidate biomarker.Related StoriesHow cell-free DNA can be targeted to prevent spread of tumorsUsing machine learning algorithm to accurately diagnose breast cancerStudy: Nearly a quarter of low-risk thyroid cancer patients receive more treatment than necessaryIn a large cohort that included 310 freshly-frozen, paraffin-embedded tissue samples (51 high-grade cancers, 67 carcinoma in situ [CIS], 84 low-grade cancers, and 108 patients with severe cystitis), AHNAK2 measurement achieved 97 percent sensitivity and 69 percent specificity in differentiating between severe cystitis with reactive urothelial atypia (RUA) vs CIS. It also displayed high sensitivity in distinguishing low versus invasive high grades and low grades vs CIS.”In our study, AHNAK2 was identified and verified in two steps as a candidate biomarker for BC,” said Barbara Sitek, PhD, Deputy Director, Medizinisches Proteom-Center (MPC), Ruhr University, Bochum, Germany. “AHNAK2 has already been proposed as a potential prognostic biomarker for clear renal cell and pancreatic cancers and is part of a urinary mRNA panel for the diagnosis of BC and prediction of tumor aggressiveness.”The investigators believe AHNAK2 could be a very helpful tool for detecting CIS recurrence or persistence, particularly because misdiagnosis of CIS can delay treatment of an aggressive malignancy or could lead to unnecessary treatment or bladder removal.BC is the second most common urogenital malignancy, with about 430,000 new cases diagnosed worldwide in 2012. About 75 percent of newly diagnosed patients have non-muscle invasive, mostly low-grade BC, and about 25 percent have high-grade BC at the stage of infiltration of smooth muscle. The presence of acute or chronic inflammation (urocystitis) with RUA can complicate diagnosis, especially when patients with BC have been purposely treated with pro-inflammatory agents. The current gold standard for tumor grading and staging of BC is the visual inspection of stained tissue thin sections by a pathologist; immunohistochemistry is also used but can be difficult to interpret.
Source:https://www.endocrine.org/news-room/2019/endo-2019—eating-later-in-the-day-may-be-associated-with-obesity Reviewed by James Ives, M.Psych. (Editor)Mar 25 2019Eating later in the day may contribute to weight gain, according to a new study to be presented Saturday at ENDO 2019, the Endocrine Society’s annual meeting in New Orleans, La.Previous studies have suggested that later timing of eating and sleeping are related to obesity, said lead author Adnin Zaman, M.D., of the University of Colorado in Denver, Colo. “However, few studies have assessed both meal and sleep timing in adults with obesity, and it is not clear whether eating later in the day is associated with shorter sleep duration or higher body fat,” she said.The study used three types of technology to record participants’ sleep, physical activity and eating patterns. “It has been challenging to apply sleep and circadian science to medicine due to a lack of methods for measuring daily patterns of human behavior,” Zaman said. “We used a novel set of methods for simultaneous measurement of daily sleep, physical activity, and meal timing patterns that could be used to identify persons at risk for increased weight gain.”Related StoriesResearchers find link between maternal obesity and childhood cancer in offspringResearch team receives federal grant to study obesity in children with spina bifidaMetabolic enzyme tied to obesity and fatty liver diseaseThe week-long study included 31 overweight and obese adults, average age 36. Ninety percent were women. They were enrolled in an ongoing weight-loss trial comparing daily caloric restrictions to time-restricted feeding, meaning they could only eat during certain hours of the day.Participants wore an activPAL electronic device on their thigh. This device measured how much time they spent in physical and sedentary activities. They also wore an Actiwatch, which assesses sleep/wake patterns. Participants were asked to use a phone app called MealLogger to photograph and time stamp all meals and snacks throughout the day.The researchers found that on average, participants consumed food throughout an 11-hour timeframe during the day and slept for about 7 hours a night. People who ate later in the day slept at a later time, but they slept for about the same amount of time as those who finished eating earlier. Later meal timing was associated with a higher body mass index as well as greater body fat.”We used a novel set of methods to show that individuals with overweight or obesity may be eating later into the day,” Zaman said. “These findings support our overall study, which will look at whether restricting the eating window to earlier on in the day will lower obesity risk.””Given that wearable activity monitors and smartphones are now ubiquitous in our modern society, it may soon be possible to consider the timing of behaviors across 24 hours in how we approach the prevention and treatment of obesity,” Zaman said.
Citation: Will automated vehicles take the stress out of driving? Research says ‘don’t count on it’ (2018, May 8) retrieved 18 July 2019 from https://phys.org/news/2018-05-automated-vehicles-stress-dont.html In their newly published Human Factors article, “Driver Vigilance in Automated Vehicles: Hazard Detection Failures Are a Matter of Time,” Eric Greenlee, Patricia DeLucia, and David Newton evaluate whether increased time on the road could reduce drivers’ ability to detect and respond appropriately to an automation failure.Greenlee, an assistant professor of human factors psychology, notes, “State-of-the-art vehicle automation systems are designed to safely maintain lane position, speed, and headway without the need for manual driving. However, there are some situations in which the automation system may fail without warning. To compensate for this, drivers are expected to remain vigilant, continuously monitor the roadway, and retake control of their vehicle should the need arise, but past research has shown that a person’s ability to remain vigilant declines as a function of time.”To test the role of vigilance in automated driving, the researchers asked 22 young adults to drive a simulated automated vehicle for 40 minutes. The drivers’ task was to observe vehicles stopped at intersections and distinguish between those that were positioned safety versus unsafely, a roadway hazard that the simulated vehicle’s automation could not detect. Participants then pressed a button on their steering wheel to indicate a dangerous vehicle.The drivers detected 30% fewer hazards at the end of the drive than at the beginning, and they also tended to react more slowly to hazards as the drive progressed. Additionally, participants reported in a post-task questionnaire that monitoring for automation failures was difficult and stressful.”Our results demonstrate that there are high costs associated with the need for sustained supervisory duty in automated vehicles,” Greenlee adds. “And the expectation that a human driver will provide reliable, attentive oversight during vehicle automation is untenable. Monitoring for automation failures can be quite demanding and stressful, suggesting that vehicle automation does not ensure an easy or carefree driving experience. As a result, vigilance should be a focal safety concern in the development of vehicle automation.” Explore further More information: Eric T. Greenlee et al, Driver Vigilance in Automated Vehicles: Hazard Detection Failures Are a Matter of Time, Human Factors: The Journal of the Human Factors and Ergonomics Society (2018). DOI: 10.1177/0018720818761711 The expectation that automated vehicles will make drivers’ jobs easier, especially if they’ve been behind the wheel for an extended period, may be more than a little flawed, according to a study by human factors/ergonomics researchers at Texas Tech University. Autonomous driving – hands on the wheel or no wheel at all Provided by Human Factors and Ergonomics Society This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.
© 2019 AFP By March 2017 Cathay reported its first annual net loss in eight years and announced a three-year overhaul to cut costs and improve efficiency.Under new chief executive officer Rupert Hogg the move appears to have paid off—last month the airline announced it had swung back into the black after two years of losses.Brendan Sobie, chief analyst at CAPA, said HK Express was too good an opportunity to pass up once it became clear the troubled HNA Group was looking to sell.”It’s in their home market, they have to look at it, and quite frankly they’d be silly not to do it,” he told AFP.According to Sobie, structural constraints and limited airport slots made it difficult for Cathay to establish a separate low-cost carrier, which was why it had previously said it would not think about a no-frills carrier until Hong Kong airport’s third runway came into operation in 2024.Losses ‘woke them up’He said the lack of space at home was also a limitation for competitors, making the move int the sector less urgent for Cathay, which had opposed budget airline Jetstar’s application to operate in Hong Kong in 2015.But the purchase was not a financial “slam dunk” for Cathay, Sobie warned, given the small margins of budget airlines in the region and the fact that HK Express reported a net loss of $18 million in 2018, according to Cathay.Shukor Yusof, the founder of aviation consultancy Endau Analytics, said Cathay’s brief foray into the red changed thinking at the company.”The losses Cathay suffered in consecutive years woke them up and they realised if they didn’t alter their thinking, they’d be marginalised and become irrelevant,” he said.”Then they saw how Singapore Airlines changed its strategy and that strategy worked,” he said, adding that Cathay should have moved into the budget sector 10 years ago.He said turning HK Express around was a “big ask”.”But if they apply stringent cost cuts and exploit the buoyant Chinese market, profitability is a possibility in two to three years,” he said.He predicted HK Express may start to price aggressively and target a select group of travellers, with mostly leisure flyers among them. “I foresee HK Express behaving and exhibiting characteristics similar to Ryanair in Europe,” he said, referring to the notoriously no-frills Irish low-cost carrier. Asia’s biggest international carrier has historically eschewed the low-cost sector, even as the region’s rising middle class has fuelled an unprecedented boom in air travel and demand for cheaper routes.But last week it finally bit the bullet, announcing it was buying HK Express for $600 million from the debt-laden Chinese conglomerate HNA Group.The move allows Cathay to take over the city’s only budget carrier and gifts it much needed slots at one of the world’s busiest transport hubs—prompting many to ask why it had taken the airline so long to make such a move.Analysts say Cathay’s reluctance to embrace the budget model was a result of its conservative way of thinking, in much the same way Nintendo was dragged kicking and screaming into the mobile gaming market after years of weak earnings.But it is not too late for the airline, they say.”It’s more like catching up rather than changing the landscape,” Jackson Wong, analyst at Huarong International Securities, told AFP, adding that Cathay realised it had to “face reality” that the budget market was something they needed to embrace.Asia-Pacific is now the world’s largest market for low-cost carriers, accounting for nearly 600 million seats in 2018, according to CAPA Centre for Aviation.Too good an opportunityAnd thanks to the region’s booming middle classes, seat capacity has quadrupled over the past decade.During that time Cathay resisted moving into the low end of the market, even as their rivals did the opposite—Singapore Airlines formed Tigerair in 2003 and Qantas followed up with Jetstar Asia.Now Asia’s skies are littered with budget carriers: Air Asia, Scoot, Nok Air, IndiGo, Lion Air, VietJet, the list keeps growing.For a while Cathay’s intransigence worked, it remained an avowedly premier—and profitable—brand.But as the regional budget scene grew, airlines in China and the Middle East began competing on longer haul flights and the more luxury frills Cathay offered. Cathay Pacific’s purchase of rival HK Express was an inevitable plunge into the no-frills market as the premier marque belatedly faces the reality that it can no longer ignore the budget sector, analysts say. Explore further New CEO Rupert Hogg has overseen a return to profit for Cathay Pacific after two years of losses and now it is now entering the budget sector Cathay Pacific to buy budget airline HK Express for $628 mn Citation: Cathay ‘faces reality’ with budget airline buy, say analysts (2019, April 2) retrieved 17 July 2019 from https://phys.org/news/2019-04-cathay-reality-airline-analysts.html This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.
20 years of Kargil: How not crossing LoC proved challengingadvertisement Next Abhishek Bhalla New DelhiJuly 13, 2019UPDATED: July 13, 2019 14:38 IST Kargil warHIGHLIGHTSFailure of intelligence and surveillance could not detect Pak movement: Gen VP MalikNot crossing LoC also proved to be a challenge: MalikArmy chief Bipin Rawat says all movements on borders can be tracked todayRecalling the challenges for the army in 1999, Gen VP Malik (Retd), the then Chief of Army Staff said on Saturday, failure of surveillance and intelligence gathering led to the Kargil intrusion 20 years back.With lessons learnt, a lot has changed since then and the Indian Armed forces have better capabilities to detect enemy movements not just in Kargil but in all border areas of Pakistan and China, Army Chief Gen Bipin Rawat said.The two along with few other veterans were part of a discussion on the Kargil War to celebrate 20 years of the victory over Pakistan.”We have revisited our capabilities to ensure such intrusions don’t happen. We have UAVs, air assets of the air force and other tactical means like quad copters for better surveillance today,” Gen Rawat said on the sidelines of the event in Delhi.Other veterans including Gen Malik shared their experiences regarding the gaps and ground situation then.”We lacked surveillance equipments and even helicopters were not capable of locating enemy locations. We were dependent on foot patrols”, he said.He also added that there was a complete intelligence failure and the then Atal Bihari Vajpayee government’s instructions not to cross the LoC added to the challenges.”I had to ask the Prime Minister not to speak about it (not crossing the LoC) in public and explained that in case we don’t achieve our targets fully we will have no option but to cross the Line of Control,” said Malik.Malik said during the war he had often seen “long faces” in South Block but never encountered this in the forward areas. “My morale was not high when I was in South Block but when I met troops in forward areas it became high,” he added.Speaking about other challenges on the ground, Malik said there was initially no assessment on what the Pakistan Army was doing and everyone thought they were Mujahideens or terrorists at high peaks.”Even military formations on ground adopted anti-militancy operational tactics. This was the reason why we suffered high number of casualties initially,” he said.He pointed out that there was a major shortage of weapons and equipment, particularly high altitude clothing.”The fact that we overcame all these challenges was because of a blend of political, military and diplomatic leadership that got involved. We met 2-3 times a day,” he said.Also read | 20 years of Kargil victory: Army soldiers trek to Batra Top, Tiger Hill to commemorate dayAlso read | Letters from KargilFor the latest World Cup news, live scores and fixtures for World Cup 2019, log on to indiatoday.in/sports. Like us on Facebook or follow us on Twitter for World Cup news, scores and updates.Get real-time alerts and all the news on your phone with the all-new India Today app. Download from Post your comment Do You Like This Story? Awesome! Now share the story Too bad. Tell us what you didn’t like in the comments Posted byAnumika Bahukhandi
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he allowed himself to be convinced. U. He said the meeting would also discuss the upsurge of Internally Displaced Persons (IDPs) and refugees, vomiting, beat making and computer training. He said the administration was also working toward an Internally Generated Revenue (IGR) of between N500 billion and N600 billion annually. says all the 600 Closed Circuit Television (CCTV) stations installed across the country are working. integrity and love for the country to genuinely reboot? the ACB filed an FIR against Kejriwal and Dikshit. and whichever one wins will have a huge effect on the health of the worlds second biggest economy over the next half-decade and beyond.
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