Human transmission likely in 2004 Thai avian flu cases

first_imgJan 24, 2005 (CIDRAP News) – Researchers who analyzed a family cluster of three cases of H5N1 avian influenza in Thailand say in an article published today that two family members probably acquired the disease from the third.The mother and an aunt of an 11-year-old girl who died of probable avian influenza last September most likely caught the disease from the girl when they cared for her in a hospital, according to the report published online by the New England Journal of Medicine.The findings appear to be the strongest evidence so far of person-to-person transmission of H5N1 avian flu since the disease became widespread in Southeast Asia last year. But the authors say they found no sign of any further transmission and no evidence of mutations that could enable the H5N1 virus to spread easily among people. Disease experts fear that such mutations could lead to a flu pandemic.The 11-year-old girl, who lived with her 32-year-old aunt, died of pneumonia on Sep 8, 2004, according to the report by Kumnuan Ungchusak, MD, MPH, of the Thai Ministry of Public Health, and colleagues from Thailand and the US Centers for Disease Control and Prevention. The girl had fallen ill 3 or 4 days after having contact with dying chickens.While the girl was in a hospital, her 26-year-old mother, who worked in a distant city, came to be at her bedside, providing “16 to 18 hours of unprotected nursing care,” the report says. The mother, who had no known exposure to poultry, became ill with a fever Sep 11 and died Sep 20.The girl’s aunt also helped care for her in the hospital, spending about 12 hours at her bedside on Sep 7. The aunt in turn fell ill with fever Sep 16 and eventually experienced pneumonia, but she gradually recovered and was discharged Oct 7.Because no adequate tissue samples were preserved, investigators could not confirm that the girl had avian flu, but her case had all the cardinal features of previous cases, the report says. Laboratory tests (reverse-transcriptase polymerase chain reaction) confirmed the disease in her mother and aunt.The mother made a 10-minute visit to her daughter’s household Sep 7 but had no known exposure to poultry before she became ill on Sep 11, the article says. The aunt’s last known exposure to poultry was 17 days before she fell ill, a period longer than the typical incubation period of 2 to 10 days.”We believe that the most likely explanation for the family clustering of these three cases of avian influenza is that the virus was transmitted directly from the infected index patient to her mother and to her aunt,” the report states.Epidemiologic investigation revealed no other human cases associated with the family cluster. In addition, RT-PCR analysis and phylogenetic analysis of the virus showed no changes that could equip it for efficient person-to-person transmission.The report says avian flu has spread from person to person before. For example, in Hong Kong’s 1997 outbreak of H5N1, some healthcare workers were found to have antibodies to the virus, and one reported mild symptoms. However, “The current family cluster is unique in that the secondary infections resulted in severe disease and death and in that the epidemiologic circumstances and laboratory findings made it possible to rule out transmission from poultry.”The lack of further transmission in the family cluster should not be an excuse for complacency, the authors write. If H5N1 avian flu remains endemic for years in the affected countries, “it is likely that such clusters will occur again, and it will be necessary to investigate each one rapidly and thoroughly to determine whether a critical change in the virus has occurred,” they conclude.Ungchusak K, Auewarakul P, Dowell SF, et al. Probable person-to-person transmission of avian influenza A (H5N1). N Engl J Med 3005;352(4):333-40 [Full text]last_img read more

D’Tigers Open Camp for FIBA World Cup

first_imgOthers include Nnamdi Gabe Vincent, Ochai Agbaji, Ogundiran Jordan, Stephen Domingo, Mehinti Tosin, Iroegbu Ikenna, TK Edogi, Agada Caleb, Ike Obiagu and Michael OguineThe trio of Aminu Alade, Chris Obekpa and Stanley Okoye who are participating in the 2019 NBA Summer League are expected to join the D’Tigers camp in Buffalo.The General Manager, Musa Adamu revealed that the five invited home-based players Agu Abuchi Ibe, Okpe Ocheibi Victor, Abdul Yahaya, Vincent Buchi Nwaiwu and Victor Koko Anthony will join the team immediately after their visa approval by the American Embassy alongside Ogoh Odaudu (Assistant Coach), Team Doctor and other officials.Other players plying their trade outside the NBA will join the camp after the first game against Dominican Republic on July 20th and 22nd in San Domingo.Nwora is assisted by Glynn Cyprien and Mfon Kokoete.Share this:FacebookRedditTwitterPrintPinterestEmailWhatsAppSkypeLinkedInTumblrPocketTelegram D’Tigers officially opened camp in Erie Community College, Buffalo, United States of America on Wednesday as Nigeria begins preparation for the 2019 World Cup in China.17 players reported to camp on Tuesday as training commenced under the leadership of Head Coach, Alex Nwora.Amongst the early birds in camp are team captain and China-based Ike Diogu, Ben Uzoh, Ajayi Joshua, Udanoh Ike Joseph, Zanna Talib, Nwamu Ike and Efe Uwadiae.last_img read more

Clayton Kershaw goes to Injured List with back stiffness

first_img“I think that the disappointment, for me, is for Clayton, because he’s as prepared as any player I’ve ever been around and starting on Opening Day means a lot to him. For him to not get to experience it for the night, I think I just feel for him.”Related Articles Newsroom GuidelinesNews TipsContact UsReport an Error Cody Bellinger homer gives Dodgers their first walkoff win of season Dodgers’ Max Muncy trying to work his way out of slow start Fire danger is on Dave Roberts’ mind as Dodgers head to San Francisco How Dodgers pitcher Ross Stripling topped the baseball podcast empire “His back stiffened up and he got treatment on it that night, felt better,” Dodgers manager Dave Roberts said. “Yesterday (Wednesday), he came in, felt a little bit better. Then this morning, just (talking) with the training staff, just to make sure we err on the side of caution, we didn’t feel that it was prudent to start him.”Roberts would not speculate on how long Kershaw will be sidelined but did say he would be eligible to come off the IL next week when the Dodgers are in Arizona.“I don’t know the timetable. And I don’t think it’d be too responsible to try to take a stab,” Roberts said. “I just hope that every day he gets better and better and we can get him on the mound again as soon as possible.”May, 22, becomes the Dodgers’ youngest Opening Day starter since a slightly-younger 22-year-old Fernando Valenzuela started the opener in 1983. May was not on the initial season-opening roster announced by the Dodgers Thursday morning but was recalled and added to the roster. Roberts said May was put on alert Wednesday and did not throw to hitters as originally planned.“He’s just very unflappable,” Roberts said of May. “He’s a very confident young man. He’s got obviously really good stuff. So it’s something where when a change of plans happens, Dustin adjusts very well. Dodgers hit seven home runs, sweep Colorado Rockies LOS ANGELES >> From 2011 to 2018, traffic jams, sellout crowds and Clayton Kershaw were givens on Opening Day. None were part of Opening Day 2020.For the second season in a row, Kershaw will open the regular season on the Injured List. In 2019, his franchise-record run of eight consecutive season-opening starts ended due to a spring-long battle with a sore shoulder.This year, however, Kershaw appeared as healthy as he had been in years during the aborted spring training in February and March, avoiding the back problems that had been an annual issue for him from 2016 through 2018. He arrived at Summer Camp having thrown multiple innings in workouts and was on track to start Thursday night’s opener against the San Francisco Giants.During a workout in the weight room on Tuesday, however, Kershaw began experiencing back stiffness and the Dodgers chose to place him on the IL and start Dustin May against the Giants.last_img read more