Fender announced Monday that it is releasing a Squier Stratocaster with a mini-USB output. That’s an electric guitar, for those of you not into that sort of thing. Whether you realize it or not, this is a huge tech story. An entry level model of the most iconic guitar in the world can now plug straight into a PC or iOS device. That opens the world of recorded music to millions of people. 9 Books That Make Perfect Gifts for Industry Ex… You don’t even need an amplifier now. It even comes with a mini-USB to 30-pin connector for plugging into an iOS device. The latest generation of iOS devices have a different port, of course, but a Lightning cable would do the trick.As someone who wants the embarrassing era of robotic pop music to die in a fire, I’m overjoyed to see Fender building a real instrument that’s this easy for the next generation to use. There’s no hiding the soul of a real guitar, and I hope this starts a tidal wave of new, human-controlled instruments for the digital era. 5 Outdoor Activities for Beating Office Burnout Tags:#Apple#Fender#music The Mac has already lowered the barrier to entry for aspiring musicians almost to the floor by pioneering the beginner-friendly recording application, GarageBand. PC users have options as well. And with the release of GarageBand for iOS, the iPad, iPhone, and iPod Touch have also become recording studios for the people. But there was still one hurdle Apple couldn’t do much about: It’s hard to get the signal from your instrument to the computer.There are two options for getting a guitar signal into a computer. You can either mic an amplifier, which takes expensive equipment and lots of experience to get a good sound, or you can use a USB interface. These vary widely in quality, and they’re often goofy to set up with your system’s audio settings. These obstacles can mean the difference between really making music and just dreaming about doing it.By releasing a Strat with USB connectivity, Fender has blown away the last obstacle. Once you have the guitar, which is available directly from Apple for $199.95, you can plug it straight into your computer and play. But it’s also a fully functional Strat you can play through an amp. jon mitchell 4 Keys to a Kid-Safe App Related Posts 12 Unique Gifts for the Hard-to-Shop-for People…
TORONTO – Canada’s telecommunications regulator says that more than 200 websites have been flagged for follow up by a multinational group investigating problems with a common type of electronic marketing that frequently involves misleading advertising.The problem sites were found last summer through an investigation co-ordinated by the Unsolicited Communications Enforcement Network (UCENet), which includes Canada.The Canadian Radio-television and Telecommunications Commission didn’t identify any of the problem websites, reveal locations or identify the types of problems detected by UCENet.An emailed statement Wednesday from the CRTC’s media representative said its investigators are working to determine how Canadians have been affected by potentially malicious activity from those websites, and whether there have been violations of Canada’s anti-spam law.The statement said the CRTC does not comment on ongoing investigations but results of the UCENet probe, which is referred to as a sweep, will be made public in the coming months.A UCENet report released early this month said that its 2017 investigation of 902 websites, including 221 flagged for follow up, found a lack of provisions for obtaining consumer consent.The multinational probe focused on affiliate marketing, in which merchants pay a commission to affiliated intermediaries that provide sales leads or sales.The UCENet report said that misleading advertising was prevalent in the affiliate marketing ecosystem.“Within minutes of beginning their research, sweepers were exposed to some form of misleading advertising,” the report said.“Some misleading advertising was directed at common internet users by affiliates in order to generate sales or traffic to a merchant’s website.”The sweep, which was conducted in June and July 2017, was co-ordinated by the U.K. Information Commissioner’s Office and the CRTC. It involved 10 agencies in six countries.It said a majority of the participating agencies found that most of the publicly available terms of services between the affiliates, the merchants and the affiliate platforms lacked appropriate guidelines for permissible unsolicited communications.“This meant that an affiliate could send unsolicited communication without it impacting the contractual relationship with the merchant or the affiliate platform,” the report said.
OTTAWA – Former federal budget watchdog Kevin Page will deliver a blunt message to premiers this week about the costs of a future national pharmacare program: if Canadians want one, taxes will have to go up.Page, who now heads a University of Ottawa think tank, will walk through the numbers Friday when he gives a presentation to the provincial and territorial leaders on what lawmakers should know about creating a cross-country, publicly funded plan for prescription drugs.The federal Liberals have put together a group of advisers, led by former Ontario health minister Eric Hoskins, to consult Canadians and explore options for a national program. The council is due to report back next year, when the topic of pharmacare is sure to become a major issue during the federal election campaign.But the burning question remains: who’s going to pay for it?Last fall, an analysis by the parliamentary budget officer estimated national pharmacare would carry a hefty cost in the neighbourhood of $20 billion a year. That’s about one percentage point of Canada’s gross domestic product and twice Ottawa’s annual deficit projections in each of the next few years.Page said there’s a solid argument to be made for national pharmacare because it would help Canadians save significantly on their out-of-pocket drug expenses and create more consistency in terms of health costs across the country. The 2017 parliamentary budget office study estimated such a plan would save Canadians more than $4 billion every year on prescriptions.But Page said Ottawa’s books are already facing a difficult fiscal situation and warned the federal balance sheet would become unsustainable if it assumed the full cost of such a program.The provinces, as a group, are in even rougher fiscal shape, he added.His presentation, which is based on a study by his Institute of Fiscal Studies and Democracy to be released Monday, recommends spending cuts and tax increases as ways to afford it.Page, however, believes there’s no way to avoid tax hikes if Canada is serious about pharmacare. One option would be to boost the GST by two points, back to seven per cent, he added.“Raising taxes is never easy, politically, in this environment, but I think if we’re going to really do something like this, we’re going to have to do it,” he said in an interview.“I don’t see any other way of really moving this forward.”Page will address the premiers in St. Andrew’s, N.B., where they will gather this week for Council of the Federation meetings. Without tax increases, governments will see their shortfalls balloon well beyond existing levels, he said.“I think it would shock people,” Page said. “Deficits would literally double.”He supports the argument that, in certain cases, public servants have a responsibility to tell taxpayers that raising taxes is in their interests as a way to make life easier for politicians to take unpopular decisions.“I think the case for a national public pharmacare program is pretty strong, even from a fiscal perspective,” he said.“Just on the numbers, it’s pretty clear that these public systems… produce much lower costs. Canadians are paying a lot for drugs, a lot.”Health-care advocates have long urged Ottawa to work with provinces and territories to implement a universal public prescription drug program that covers all Canadians.Critics call the country’s current system an inefficient, expensive patchwork that has left 3.5 million Canadians unable to afford the medication they need.— Follow @AndyBlatchford on Twitter
Mike Trout has put up an amazing couple of seasons in Major League Baseball, not just for someone as young as he is, 22, but for anyone. His 19.62 wins above replacement (WAR) over his first two full seasons ranks as the 36th best two-year stretch for any batter ever. Only nine batters have had a better stretch by the age of 25, and they’re essentially a who’s who of Hall of Famers: Mickey Mantle, Babe Ruth, Ted Williams, Ty Cobb, Lou Gehrig, Rogers Hornsby, Eddie Collins, Jimmie Foxx and Willie Mays. The list of players who put up better numbers at an earlier age doesn’t have any names on it.Conventional wisdom seems to be that Trout, an outfielder for the Los Angeles Angels of Anaheim, is only going to get better. Much of that analysis relies explicitly on the traditional aging curve or on similar logic: MLB players and prospects typically improve rapidly through their late teens and early 20s, peaking around age 27. Trout was 21 last season, ergo, he has several years of improvement in his future.But regression to the mean dictates that the better the performance you’re looking at, the less likely it is to be duplicated. Players who put up huge numbers like Trout’s (or anywhere close) this early in their careers have a very high likelihood of having All Star- and/or Hall of Fame-quality careers. But how often do they improve on these initial breakout performances?I’ve taken all the players who put up more than 15 WAR over a two-year period at any point in their careers and broken them down by the age when they first accomplished the feat. Then I asked a simple question: Did they ever manage a better two-year period?The size of the bubbles represent how many players accomplished the “15 WAR in two years” milestone, and the y value of the bubbles show the percentage of those players who surpassed that milestone.As you can see, the odds of someone Trout’s age improving are ostensibly 100 percent, but that bubble represents a single data point: Alex Rodriguez. If you move to the much larger group of players between ages 22 and 24, the odds drop into the 50 percent range.On the other hand, some players who never managed a stronger two-year stretch still managed a strong third season immediately after their initial two-year breakout. In such cases, they may set a new two-year “peak” that overlaps the original. Thus, while never replicating their original two-year performance, they end up with a better two years on the books. This is the most likely time for a player to establish a new “peak,” because pulling it off only takes one well-timed season instead of two.Of the 75 players who achieved 15-plus WAR over two seasons, only 22 managed to replicate or exceed the feat later in their career. But an additional 15 improved their benchmark the following season. Counting these cases, the odds of a player’s two-year performance being his two-year peak drop substantially. Factoring this in and cleaning up the data a bit (I put the players in rolling 3-year age groups) gives us a result like this:For Trout’s case, there are a few other factors to consider:Cutting both ways: Trout’s numbers are higher than average in his age group. This makes it more likely that he’s a uniquely great player, but it also makes the numbers inherently less likely to be surpassed.Cutting in his favor: Trout was 21 last season, and his group covers players age 21 to 23. This gives him a slightly longer career ahead, and thus more chances to put up better seasons. Further, having pulled off such great numbers at such an early age probably increases the chances that he’s truly special. But there’s not really enough data to demonstrate this effect.Cutting against him: Trout is probably less likely to achieve a new two-year peak this year, because the strongest of the two seasons in this run was the first. Improving on his peak will require him posting better than 10.8 WAR — a feat which has happened only 22 times before, six of which were by Babe Ruth. (Also, though outside the scope of this post, it’s possible that the aging curve is no longer as favorable as it used to be).All things considered, the answer to whether Trout has peaked yet is “probably not,” though I think it’s far from being as much of a certainty as many people seem to think. Even some of the Hall of Famers mentioned above peaked early, and Trout’s start has been so strong that he could potentially do the same and still end up joining them.
Danilo insisted that Manchester City have to overcome their first major crisis of the season and fully focus on the upcoming Champions League game against Liverpool as they still can advance to the semifinals.The Brazilian full-back admitted that this week has been a huge disappointment for the whole team as they were beaten by Liverpool 3-0 and then lost the derby despite leading 2-0 after the first half – but now, they have to forget all this.The former Real Madrid player spoke about his side’s morale as he said, according to Belfast Telegraph:“Well, without doubt, the atmosphere, the feeling, is of sadness, of disappointment.”Report: City are stunned by Norwich George Patchias – September 14, 2019 Manchester City was stunned by Norwich City in todays Premier League clash.Much has been made in recent days of the potential impact of Aymeric…“We started the game really well, but we must return to the pitch as soon as possible because on Tuesday we have another big challenge to overcome a result.”“Without any doubt (the City fans were great). We need to thank them all.”“Not just for today but all the season, but especially the atmosphere they created today was amazing.”“They helped us until the last minute and I am sure they could help us a lot against Liverpool if they are able to create that atmosphere again and try to help us to overcome the result.”
The closure of the Central District drift gillnet fishery and Upper Subdistrict East Foreland Section set gillnet fishery is being implemented to reduce the harvest of Kenai River sockeye salmon. The set gillnet fishery in the Kasilof Section within 600 feet of shore is warranted in order to harvest Kasilof River sockeye salmon. Facebook0TwitterEmailPrintFriendly分享The Department of Fish and Game has announced the closure of drift gillnetting in the Central District of Upper Cook Inlet and also the closure of set gillnetting in the East Foreland Section of the Upper Subdistrict from 7:00 a.m. until 7:00 p.m., today. Brian Marston with DF&G: “On July 24, Upper Cook Inlet Commercial Fisheries staff estimated the Kenai River sockeye salmon run will be less than 2.3 million fish. With this updated run assessment, the inriver goal for Kenai River sockeye salmon is now 900,000-1,100,000 fish. Based on the current passage estimate of sockeye salmon in the Kenai River of 354,000 fish through July 24, even 3-day late run timing models do not project the minimum inriver goal will be met without a reduction in harvest of this stock.” In the Kasilof River, the total estimated sockeye salmon passage through July 24 is approximately 243,000 fish. Based on average to 3-day late run timing models, passage into the Kasilof River is 69% to 75% complete and projects a final passage estimate of 324,400 to 352,000 fish, according to DF&G. However, set gillnetting will be open within 600 feet of the mean high tide mark on the Kenai Peninsula shoreline in the Kasilof Section of the Upper Subdistrict from 11:00 a.m. until 11:00 p.m., today.
WILMINGTON, MA — Below are 5 things to do in Wilmington on Tuesday, June 11, 2019:#1) How To Make Your Own Ice CreamThe Wilmington Memorial Library (175 Middlesex Avenue) is holding a presentation on how to make your own ice cream at 7pm. I scream, you scream, we all scream for ice cream! Join Library Associate Lisa Crispin for a demonstration on how to make everyone’s favorite sweet summer treat. No ice cream maker? No problem! Both ice cream maker and no churn recipes will be shown. Handouts and samples provided. Register HERE.#2) Wilmington Finance Committee’s Appointing CommitteeThe Wilmington Finance Committee’s Appointing Committee meets at 7pm in Town Hall’s Room 9. Read the agenda HERE.#3) Tour Of Wilmington Town MuseumThe Town Museum (430 Salem Street) is open from 10am to 2pm. Come explore Wilmington’s history. Free admission.#4) Town Beach Open The Town Beach is open today. Lifeguards are on duty from 10am to 8pm. Admission is FREE for residents. Proof of residency is required. Learn more HERE.#5) Angels In Motions MeetingAngels In Motion meets every Tuesday, from 9:30am to 2:30pm at the Wilmington Knights of Columbus Hall (112 Middlesex Avenue). The club provides a great opportunity for seniors to meet new friends or reacquaint with old ones. A luncheon is served as noon. Free. Handicapped accessible.Like Wilmington Apple on Facebook. Follow Wilmington Apple on Twitter. Follow Wilmington Apple on Instagram. Subscribe to Wilmington Apple’s daily email newsletter HERE. Got a comment, question, photo, press release, or news tip? Email email@example.com.Share this:TwitterFacebookLike this:Like Loading… Related5 Things To Do In Wilmington On Tuesday, June 25, 2019In “5 Things To Do Today”5 Things To Do In Wilmington On Tuesday, September 3, 2019In “5 Things To Do Today”5 Things To Do In Wilmington On Tuesday, July 30, 2019In “5 Things To Do Today”
Luxury cars Sedans More about 2020 Mercedes-Benz CLA-Class Preview • 2020 Mercedes-Benz CLA250 first drive: Now actually feels like a premium car Share your voice Post a comment 2020 Mercedes-Benz GLE450 review: More luxurious and techy than ever Not so entry-level anymore. Mercedes-Benz When the Mercedes-Benz CLA first arrived in the US, it marked a big shift for the German luxury brand. The C-Class was no longer the gateway model and the CLA was priced aggressively to start just around $30,000. That figure is long gone, friends.For 2020, Mercedes-Benz said in a Thursday release that the CLA will cost $37,645 after a $995 destination charge. For starters, that’s almost $7,000 more than what the first CLA cost originally. Secondly, that’s a pretty hefty price bump over the 2019 model. Buyers will fork over $3,550 more for the new model. Add all-wheel drive and buyers will flirt with $40,000 for a base model at $39,645.To be fair, the CLA does differentiate itself from the brand’s new entry-level model, the A-Class. For starters, the CLA comes with a 2.0-liter turbo-4 engine that musters 221 horsepower and 258 pound-feet of torque. In contrast, the A-Class’s 2.0-liter turbo-4 makes just 188 hp and 221 pound-feet of torque. The CLA is also larger than before and boasts that swankier coupe-like look that’s all the rage these days.Standard equipment for all CLA models includes 18-inch wheels, LED headlights and taillights, a 7-inch digital instrument cluster and a matching 7-inch touchscreen for infotainment purposes. The brand’s latest infotainment system, MBUX, is also on board with its “Hey Mercedes” command ready to answer your questions and assist. Additional driver assistance packages and premium goodies will increase the CLA’s price well past $40,000 before other fees and taxes.Is all of it too pedestrian, perhaps? There will also be Mercedes-AMG models to heat things up. The CLA35 and CLA45 models will boast 302 hp and nearly 400 hp, respectively. Prices aren’t available for the sportier of CLAs, but expect healthy premiums over the standard car. Buyers will find the regular CLA arriving at dealers this fall. Now playing: Watch this: Tags 2019 Mercedes-Benz S560 Coupe review: Still the luxury benchmark 38 Photos 0 2019 Mercedes-Benz A220: The entry-level luxury sedan… The 2020 Mercedes-Benz CLA250 is more design-focused than ever More From Roadshow 2019 Cadillac Escalade review: Large, luxurious and long in the tooth Mercedes-Benz 6:01 Mercedes-Benz
Professor Maneesha S InamdarTwitter [Representational Image]A group of scientists has created a mouse model study that may be able to cure leukaemia. The model helps to study blood disorders and bone marrow that could help find a cure for blood and bone marrow cancer.The model was created by a research team led by Professor Maneesha S Inamdar at Jawaharlal Nehru Centre for Advanced Scientific Research (JNCASR) in Bengaluru. Their findings have been published in medical journal Blood.The research team has discovered a stem cell protein called ‘asrij’ (meaning blood in Sanskrit), has found it plays a key role in preventing myeloproliferative disease, a condition characterised by excessive production of mature blood cells, reports TOI.The article named as “Asrij/OCIAD1 suppresses CSN5-mediated p53 degradation and maintains mouse hematopoietic stem cell quiescence” is a contribution of the research of the team comprising of Saloni Sinha, Tirath Raj Dwivedi, Roja Yengkhom, Venkata Anudeep Bheemsetty, Takaya Abe, Hiroshi Kiyonari, K VijayRaghavan and Inamdar.According to reports, 90 per cent of cancer cases are caused due to the mutation of a protein which regulates cell production-p53. “Only 11 per cent of hematologic malignancies (cancer in the cells of blood-forming tissue) have mutant p53. Mechanisms that cause wild type p53 dysfunction and promote leukaemia are inadequately deciphered” read the journal.”Despite no significant mutation of p53, we found levels of asrij were low, causing uncontrolled production of new cells”, Inamdar told TOI.According to one of the researcher Saloni, the protein asrij protects p53 and helps in preventing cancer. Without asrij, p53 is destroyed and the blood stem cells multiply making it cancerous.She said that the new research by the team explains how some cancer cells develop without a mutation in p53. It is a well-known fact among the scientists that mutations in p53 lead to cancer but they were unable to figure out how and this study will help them to understand it.The research was done in collaboration with RIKEN CDB, Kobe, Japan and the National Centre for Biological Sciences, Bengaluru.