Human transmission likely in 2004 Thai avian flu cases

first_imgJan 24, 2005 (CIDRAP News) – Researchers who analyzed a family cluster of three cases of H5N1 avian influenza in Thailand say in an article published today that two family members probably acquired the disease from the third.The mother and an aunt of an 11-year-old girl who died of probable avian influenza last September most likely caught the disease from the girl when they cared for her in a hospital, according to the report published online by the New England Journal of Medicine.The findings appear to be the strongest evidence so far of person-to-person transmission of H5N1 avian flu since the disease became widespread in Southeast Asia last year. But the authors say they found no sign of any further transmission and no evidence of mutations that could enable the H5N1 virus to spread easily among people. Disease experts fear that such mutations could lead to a flu pandemic.The 11-year-old girl, who lived with her 32-year-old aunt, died of pneumonia on Sep 8, 2004, according to the report by Kumnuan Ungchusak, MD, MPH, of the Thai Ministry of Public Health, and colleagues from Thailand and the US Centers for Disease Control and Prevention. The girl had fallen ill 3 or 4 days after having contact with dying chickens.While the girl was in a hospital, her 26-year-old mother, who worked in a distant city, came to be at her bedside, providing “16 to 18 hours of unprotected nursing care,” the report says. The mother, who had no known exposure to poultry, became ill with a fever Sep 11 and died Sep 20.The girl’s aunt also helped care for her in the hospital, spending about 12 hours at her bedside on Sep 7. The aunt in turn fell ill with fever Sep 16 and eventually experienced pneumonia, but she gradually recovered and was discharged Oct 7.Because no adequate tissue samples were preserved, investigators could not confirm that the girl had avian flu, but her case had all the cardinal features of previous cases, the report says. Laboratory tests (reverse-transcriptase polymerase chain reaction) confirmed the disease in her mother and aunt.The mother made a 10-minute visit to her daughter’s household Sep 7 but had no known exposure to poultry before she became ill on Sep 11, the article says. The aunt’s last known exposure to poultry was 17 days before she fell ill, a period longer than the typical incubation period of 2 to 10 days.”We believe that the most likely explanation for the family clustering of these three cases of avian influenza is that the virus was transmitted directly from the infected index patient to her mother and to her aunt,” the report states.Epidemiologic investigation revealed no other human cases associated with the family cluster. In addition, RT-PCR analysis and phylogenetic analysis of the virus showed no changes that could equip it for efficient person-to-person transmission.The report says avian flu has spread from person to person before. For example, in Hong Kong’s 1997 outbreak of H5N1, some healthcare workers were found to have antibodies to the virus, and one reported mild symptoms. However, “The current family cluster is unique in that the secondary infections resulted in severe disease and death and in that the epidemiologic circumstances and laboratory findings made it possible to rule out transmission from poultry.”The lack of further transmission in the family cluster should not be an excuse for complacency, the authors write. If H5N1 avian flu remains endemic for years in the affected countries, “it is likely that such clusters will occur again, and it will be necessary to investigate each one rapidly and thoroughly to determine whether a critical change in the virus has occurred,” they conclude.Ungchusak K, Auewarakul P, Dowell SF, et al. Probable person-to-person transmission of avian influenza A (H5N1). N Engl J Med 3005;352(4):333-40 [Full text]last_img read more

ITTF World Tour Hungarian Open:Japanese teenagers win big in Budapest

first_img Loading… A fourth ITTF World Tour men’s singles title for Harimoto, this was totally new territory for Uda, whose previous best on the circuit was a second round exit at last year’s Czech Open. In Budapest he ended European hopes, defeating Austria’s Robert Gardos (11-6, 7-11, 16-18, 11-7, 11-6, 11-7), before overcoming England’s Liam Pitchford, the no.9 seed (11-13, 11-8, 11-5, 5-11, 11-6, 11-7) en route to Sunday’s silver medal finish. While Harimoto got his hands on gold without ever being extended the full seven games distance, it was somewhat different for fellow Japanese star, Mima Ito, top seed in the women’s singles event. In the final against Chinese Taipei’s Cheng I-Ching, the no.3 seed, down 2-3 in games, in the sixth she trailed 2-7 before recovering to win her eighth ITTF World Tour women’s singles title (11-7, 1-11, 11-6, 7-11, 2-11, 11-9, 11-7). “We have played each other a number of times, so we know each other’s game really well. It is never easy to come up against her. Game six was very important when I changed the direction of play. For the final game I played stronger and I found my rhythm. I am very happy about taking the trophy here in Budapest.” – Mima Ito Earlier in the event, Ito had been required to break down defensive play; at the quarter-final stage she beat colleague Hitomi Sato, the no.6 seed (9-11, 7-11, 11-6, 11-8, 11-1, 11-2), prior to overcoming Germany’s Han Ying, the no.14 seed (11-7, 11-9, 10-12, 11-7, 11-4). FacebookTwitterWhatsAppEmail分享 Japanese duo Tomokazu Harimoto (aged 16) and Mima Ito (19) won the respective men’s singles and women’s singles titles at the 2020 ITTF World Tour Hungarian Open in Budapest on Sunday 23rd February. Their success came the day after Japan’s Miu Hirano and Kasumi Ishikawa had secured the women’s doubles top prize, Germany’s Benedikt Duda and Patrick Franziska had struck men’s doubles gold, and Hong Kong China’s Wong Chun Ting and Doo Hoi Kem had emerged the mixed doubles champions. Harimoto, the top seed, entered the action in Budapest with a point to prove. The previous month at the All Japanese National Championships he had been beaten in the men’s singles final by Yukiya Uda. Furthermore, the last time he had played in Budapest, at the Liebherr 2019 World Championships, he had experienced a shock fourth round defeat. In determined fashion, debts were settled and gremlins laid to rest; after ending German hopes by beating Benedikt Duda (12-10, 9-11, 11-6, 12-10, 9-11, 11-4) and Dimitrij Ovtcharov, the no.3 seed (11-9, 11-8, 11-4, 11-8), Harimoto then got his revenge over Uda in the final (7-11, 11-8, 11-2, 11-6, 11-9) to seal his first international title of 2020. “I was looking forward to this final to take my revenge after this year’s All Japan Championships. After winning the second game I was in control of the match, my confidence grew point by point and I started to play at a higher level. I am very happy about the title and the fact I was able to elevate my game to a high level in Budapest.” – Tomokazu Harimoto Promoted ContentThese TV Characters Left The Show And It Just Got BetterThe Highest Paid Football Players In The WorldTop 10 Most Romantic Nations In The World5 Of The World’s Most Unique Theme ParksWho Is The Most Powerful Woman On Earth?5 Of The World’s Most Unique Theme Parks2020 Tattoo Trends: Here’s What You’ll See This Year10 Asian Actresses Of Irresistible Beauty9 Best Movie Robots Of All Time10 Greatest Disney Female Villains We Love AnywaysWhich Country Is The Most Romantic In The World?What Happens To Your Brain When You Play Too Much Video Games?last_img read more

Hope has new life on Rose Parade float

first_imgThe 1,500 special red roses in Laurie Wolowic’s floating rose garden will be displayed near the rear of this year’s Donate Life Rose Parade float. The Studio City woman will be there with them, walking beside the “Life Takes Flight” float in memory of her brother, Mike. He died a few days before Thanksgiving five years ago after falling from a ladder while doing house repairs. His donated organs gave life to four people. “I wanted to do something to honor him,” Laurie was saying Monday, receiving a few more cartons of roses sent to her by donor families from all over the world. But all these families, like Laurie’s own, had to grieve and suffer to bring joy and elation to the families of people who would now live. People like Joanne Foley in Woodland Hills, whose new kidney from a donor allowed her to see her grandson play his senior year of football this year at Moorpark High. She was at home Monday sending a Christmas card and another thank you note to the family of the North Carolina man whose kidney she now has. A donated kidney from a friend brought joy to Dale Wade Davis of North Hollywood who will now be around to see his two young daughters, Hayley and Rebecca, grow up. There are 1,500 poignant, moving stories in Laurie Wolowic’s floating rose garden. “The rose is a meaningful symbol of love, loss and renewal that represents something different to every donor family,” she says. “To some it is hope, to others it is grief, and to others gratitude.” Thanksgiving is still hard for her family, she says. Her parents were married on Thanksgiving Day more than 50 years ago, and it was tradition for all her nine brothers and sisters to come home and be one family again every Thanksgiving. When Mike fell from that ladder five years ago, a large part of the heart of the Wolowic family died with him. “But we remember the four families who are truly thankful for a second chance at life,” Laurie says. “I hear this incredible gratitude repeated from transplant recipients around the country. “When I speak with donation groups from Europe and Asia, I realize that no matter what language you speak or culture you live in, the need for organ and tissue donation is universal. “The desire to celebrate our loved ones and their gift of life connects us all.” For more information on Family Circle Roses or becoming an organ donor, go online to www.donatelifefloat.org, or give Laurie a call at 818-720-6300.160Want local news?Sign up for the Localist and stay informed Something went wrong. Please try again.subscribeCongratulations! You’re all set! AD Quality Auto 360p 720p 1080p Top articles1/5READ MOREWhicker: Clemson demonstrates that it’s tough to knock out the champFrom mothers and fathers in Germany, sisters and brothers in Italy, husbands and wives in South Korea, and kids and grandkids in Turkey and Vietnam. All of them wanting Laurie to plant a rose for a loved one in her floating rose garden. “Two years ago, when we started the Family Circle Rose Garden, we received 300 roses from donor families in 36 states,” Laurie said. “Last year, we had 1,000 roses from all 50 states and Canada. This year, we’ll have 1,500 roses from every state and 15 countries.” Her floating rose garden is beautiful, but bittersweet. On one hand, it shows that more families from all over the world consider organ donation a viable choice, and that’s a good thing. last_img read more