Human transmission likely in 2004 Thai avian flu cases

first_imgJan 24, 2005 (CIDRAP News) – Researchers who analyzed a family cluster of three cases of H5N1 avian influenza in Thailand say in an article published today that two family members probably acquired the disease from the third.The mother and an aunt of an 11-year-old girl who died of probable avian influenza last September most likely caught the disease from the girl when they cared for her in a hospital, according to the report published online by the New England Journal of Medicine.The findings appear to be the strongest evidence so far of person-to-person transmission of H5N1 avian flu since the disease became widespread in Southeast Asia last year. But the authors say they found no sign of any further transmission and no evidence of mutations that could enable the H5N1 virus to spread easily among people. Disease experts fear that such mutations could lead to a flu pandemic.The 11-year-old girl, who lived with her 32-year-old aunt, died of pneumonia on Sep 8, 2004, according to the report by Kumnuan Ungchusak, MD, MPH, of the Thai Ministry of Public Health, and colleagues from Thailand and the US Centers for Disease Control and Prevention. The girl had fallen ill 3 or 4 days after having contact with dying chickens.While the girl was in a hospital, her 26-year-old mother, who worked in a distant city, came to be at her bedside, providing “16 to 18 hours of unprotected nursing care,” the report says. The mother, who had no known exposure to poultry, became ill with a fever Sep 11 and died Sep 20.The girl’s aunt also helped care for her in the hospital, spending about 12 hours at her bedside on Sep 7. The aunt in turn fell ill with fever Sep 16 and eventually experienced pneumonia, but she gradually recovered and was discharged Oct 7.Because no adequate tissue samples were preserved, investigators could not confirm that the girl had avian flu, but her case had all the cardinal features of previous cases, the report says. Laboratory tests (reverse-transcriptase polymerase chain reaction) confirmed the disease in her mother and aunt.The mother made a 10-minute visit to her daughter’s household Sep 7 but had no known exposure to poultry before she became ill on Sep 11, the article says. The aunt’s last known exposure to poultry was 17 days before she fell ill, a period longer than the typical incubation period of 2 to 10 days.”We believe that the most likely explanation for the family clustering of these three cases of avian influenza is that the virus was transmitted directly from the infected index patient to her mother and to her aunt,” the report states.Epidemiologic investigation revealed no other human cases associated with the family cluster. In addition, RT-PCR analysis and phylogenetic analysis of the virus showed no changes that could equip it for efficient person-to-person transmission.The report says avian flu has spread from person to person before. For example, in Hong Kong’s 1997 outbreak of H5N1, some healthcare workers were found to have antibodies to the virus, and one reported mild symptoms. However, “The current family cluster is unique in that the secondary infections resulted in severe disease and death and in that the epidemiologic circumstances and laboratory findings made it possible to rule out transmission from poultry.”The lack of further transmission in the family cluster should not be an excuse for complacency, the authors write. If H5N1 avian flu remains endemic for years in the affected countries, “it is likely that such clusters will occur again, and it will be necessary to investigate each one rapidly and thoroughly to determine whether a critical change in the virus has occurred,” they conclude.Ungchusak K, Auewarakul P, Dowell SF, et al. Probable person-to-person transmission of avian influenza A (H5N1). N Engl J Med 3005;352(4):333-40 [Full text]last_img read more

Eagles star begins New Year on a glorious note

first_img Promoted Content7 Universities Where Getting An Education Costs A Hefty PennyWho Earns More Than Ronaldo?The Very Last Bitcoin Will Be Mined Around 2140. Read More7 Universities In The World With The Highest Market ValueThe 10 Best Secondary Education Systems In The WorldWhat Happens To Your Brain When You Play Too Much Video Games?Who’s The Best Car Manufacturer Of All Time?6 Most Handsome Indian ActorsTop 7 Best Car Manufacturers Of All Time7 Interesting Facts About GoT Star Maisie WilliamsBirds Enjoy Living In A Gallery Space Created For ThemBest & Worst Celebrity Endorsed Games Ever Made It was the first-timers who drew the first blood when Cameroonian forward Leandre Tawamba Kana gave Paolo Sergio’s men the lead in the 18th minute. Loading… But Abderrazak Hamdallah equalised for Al Nassr just before the hour mark meaning both teams had to settle for a 1-1 draw after the 90 minutes. Read Also:Top European club keen on Ahmed Musa deal in January Al Nassr had the last laugh, though, triumphing 5-4 in the ensuing penalty shoot out. Ahmed Musa and Al Nassr are favourites to also defend their Saudi Pro League title as the champions are the clear league leaders, enjoying a five-point advantage over second-place Al Hilal. FacebookTwitterWhatsAppEmail分享 center_img Musa becomes the first Nigerian star abroad to win a trophy in the New Year after playing a key role in Al Nassr’s penalty shoot-out victory over 2019 King’s Cup winners Al Taawon at the King Abdullah Stadium. It is the second title Musa will be celebrating since moving to Arabia following a league title triumph at the end of the 2018/19 season. The Saudi Super Cup is a one-off final match between the previous year’s league champions and the King’s Cup winners. Al-Nassr have not won the Cup despite this being their third appearance in the competition, finishing as runners-up in both the 2014 and 2015 editions of the Super Cup. For Al-Taawoun’s, it’s their first appearance in the competition.Advertisement Nigeria international and Super Eagles captain, Ahmed Musa, claimed his second trophy in Saudi Arabia after helping Al Nassr beat Al Taawon to the Saudi Super Cup on Saturday night.last_img read more

Deepak Kumar’s car stolen from wedding function

first_imgNew Delhi: Preparing for Tokyo Olympics, shooter Deepak Kumar suffered a jolt on the personal front as the Asian Games silver medallist’s car, a Honda WR-V, was stolen while he was attending the wedding ceremony of his sister-in-law.The incident took place around 2:30 am in the night on Tuesday as the car was parked outside the VIP Park, JP Tent house in Keshav Puram.“The response has been a bit slow so far (from the police). See these are matters which can take my focus away from the game. But I am not letting that happen,” Kumar, who secured an Olympic quota in the 10m air rifle event at the Asian Championships last year, told IANS.“I am preparing for the World Cup (in Delhi from March 15 at the Dr Karni Singh Ranges) and I will continue to do what I have been doing, train harder and give my best,” said the 32-year old. A similar incident had happened with Kumar in 2018 when valuables were stolen from his car in South Delhi’s Ambedkar Nagar. (IANS)Also Read: Expecting great result from Indian shooters: Shooter Deepak KumarAlso Watch: AJYCP members form human chain across Assam to protest against CAA 2019last_img read more

Q&A with Fresno State Collegian sports editor

first_imgWith the 2014 Trojan football team’s first game on the horizon, Daily Trojan sports editor Aubrey Kragen interviewed Fresno State Collegian sports editor Christopher Livingston to give USC fans a better picture of what to expect in Saturday’s game against the Bulldogs. DT: USC beat Fresno State 45-20 in last year’s Las Vegas Bowl to end the season. Do you think that will weigh on the Bulldogs at all?Collegian: Absolutely not. Fresno State has a new look offensively heading into the season, and even the veteran leadership on the team will not dwell on the loss. USC is by any means a tough opponent, and Fresno State is up to the challenge of facing the Trojans again.Fresno State has always had a philosophy of “one game at a time.” The loss at Las Vegas was a demoralizing end to an otherwise productive season, but now that it is a new season with a new squad, the focus is to be able to recover and press ahead. DT: How are you going to replace former QB Derek Carr, who led the nation in pass yards last year?Collegian: There is no way to replace Derek Carr. He had one of the best seasons a Fresno State quarterback could have and left the school with 27 school records and 41 conference records.What the Bulldogs can do, however, is try to balance their approach.As of right now, head coach Tim DeRuyter has not announced who will start Saturday’s game; in fact, he has said that it will be a game-day decision. However, we will see both junior Brian Burrell, who saw action in five games as Carr’s backup last season, and incoming transfer Brandon Connette on the field this Saturday.It is definitely a tough decision, and a big void that the Bulldogs will attempt to fill. DT: Prediction?Collegian: It will be a tough contest for the Bulldogs, no doubt. Even with “the cream of the crop” on the field, the Las Vegas Bowl turned out to be a sloppy contest for the team. With the season beginning against USC, add the fact that the Bulldogs are debuting a new core on offense, it looks like an uphill battle for Fresno State.Defensively, the Bulldogs have more experience and are looking to be stronger in that category. With safety Derron Smith and middle linebacker Karl Mickelsen maturing, I do believe that defense will be the strong point for Fresno State this season.As I said, the Bulldogs are up to the challenge and will not let the sting from a postseason loss get them down. But realistically, this is not the right time to experiment on offense. The question marks that surround the quarterback battle are too large to declare this an absolute victory for the Bulldogs:Fresno State 17, USC 28. DT: The 2013 Trojans heard the phrase, “If you have two quarterbacks, you don’t have any,” all too often at the beginning of last season. Do you have confidence that the current quarterback battle between Brian Burrell and Brandon Connette will turn out better than USC’s did?Collegian: My opinion is that we will see something similar to how the Fresno State running back battle went last year, when we saw a balance of playing time between both Josh Quezada and Marteze Waller. Obviously, with Carr, the Bulldogs had more of an aerial attack and did not use the ground game as much.Echoing that phrase, this year could be the return of a heavy ground game while the Bulldogs figure out who will be their consistent No. 1 signal caller. Chances are, the season could end with two quarterbacks still rated top of the depth chart. Will we see a total change in the depth chart by the middle of the season? I don’t doubt it.last_img read more